Cancer: when friends become foes, and how to make them friends again


Lecture Overview

Professor Gerard Evan FRS FMedSci, Sir William Dunn Professor of Biochemistry, Department of Biochemistry 18.00 - 19.00

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Cancer affects almost one in two persons worldwide, making it a devastatingly common disease. However, each cancer arises from an individual cell, of which there are some hundred thousand billion in each human. So, while cancer is a common disease, it is nonetheless a vanishingly rare phenomenon. Furthermore. Since cancers arise by random mutation in affected cells, every cancer is different from every other. Indeed, as random mutation continues during cancer development and progression, it is possible that every cancer cell in every cancer in every patient is unique. Modern genomic technologies have confirmed these facts and exposed cancer as a bewilderingly and endlessly complex and diverse. How can we possibly understand, let alone treat, such a protean disease? I will present evidence that this apparent complexity may be a distraction. Despite their many differences, cancers are remarkably similar to each other and share remarkably common underlying features and mechanisms. The clue to understanding these mechanisms comes from an appreciation that cancers are aberrant versions of normal processes that serve to maintain and protect us during our lives. These “friends” only become our “enemies” when they are hacked by cancer-causing mutations. It even seems that cancers carry within them mechanisms to reverse themselves, perhaps opening up an entirely novel approach to cancer treatment.

Bristol-Myers Squibb Lecture Theatre, Department of Chemistry

Bristol-Myers Squibb Lecture Theatre, Department of Chemistry

How to get there

The Lecture Theatre is accessed from Lensfield Road, via a shared entrance road with the Scott Polar Research Institute (located on the left of the access way). The entrance to the Lecture Theatre is on right hand side towards the end of the shared entrance road. There is no direct access to the Lecture Theatre from the Department of Chemistry main entrance.


Please use the Queen Anne Car Park or the Grand Arcade Car Park. There is also on street parking (pay and display)

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Bristol-Myers Squibb Lecture Theatre, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW

Telephone: 01223 336300